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Pacira BioSciences, Inc. (NASDAQ:PCRX), the industry leader in its commitment to deliver innovative, non-opioid pain therapies to transform the lives of patients, today announced that it has concluded patient enrollment in Part A of its Phase 2 ASCEND study evaluating PCRX-201 (enekinragene inzadenovec) for the treatment of osteoarthritis (OA) of the knee. This milestone marks the first stage of a two-part, multicenter trial designed to evaluate the safety and efficacy of PCRX-201, the company's novel, locally administered gene therapy candidate for osteoarthritis of the knee. The company expects to report topline results from Part A of the study near the end of 2026.
PCRX-201 is injected locally into the knee joint to boost cellular production of interleukin-1 receptor antagonist (IL-1Ra), and block interleukin-1 pathway activation to improve chronic inflammation, pain, and function. PCRX-201's unique design also features an inducible promoter to mimic the body's natural response to inflammation by "turning on" the expression of IL-1Ra when inflammation is present in the joint and turning off expression once inflammation is quelled.
"Concluding enrollment in Part A of the ASCEND study for PCRX-201 represents a significant milestone in our Phase 2 development program," said Jonathan Slonin, M.D., MBA, Chief Medical Officer at Pacira BioSciences. "Building on encouraging results from our Phase 1 study, this accomplishment underscores the strategic execution of our clinical team and the growing recognition of the potential of PCRX-201 to provide sustained relief, addressing the underlying inflammatory drivers of OA through local administration."
Posted In: PCRX
