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— Mec-V demonstrates median OS of 21.5 months in patients with treatment-refractory leiomyosarcoma, liposarcoma, and undifferentiated pleomorphic sarcoma compared with approximately 12 months with approved agents
— Mec-V safety profile as monotherapy, and in combination with anti-PD-1 antibody, was manageable and consistent with conditional binding of the AXL target restricted to the tumor microenvironment
SAN DIEGO, Nov. 07, 2025 (GLOBE NEWSWIRE) -- BioAtla, Inc. (NASDAQ:BCAB), a global clinical-stage biotechnology company focused on the development of Conditionally Active Biologic (CAB) antibody therapeutics for the treatment of solid tumors, today announced clinical data in a poster titled "Median OS of 21.5 months among 44 patients with treatment-refractory leiomyosarcoma, liposarcoma, and undifferentiated pleomorphic sarcoma treated with mecbotamab vedotin, an AXL-targeting ADC," at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting, being held November 5–9, 2025, in National Harbor, Maryland.
Mec-V is a CAB antibody–drug conjugate (ADC) targeting AXL, a receptor tyrosine kinase overexpressed in various solid tumors including sarcoma. Mec-V, developed using BioAtla's proprietary CAB technology, conditionally binds to AXL under acidic-pH conditions, enabling tumor-specific delivery of its cytotoxic payload while minimizing off-tumor toxicity.
In the Phase 2 clinical trial, 79 patients with advanced soft tissue sarcomas were treated with Mec-V either as monotherapy (n=54) or in combination with anti–PD-1 antibody (n=25). A focused efficacy analysis of OS was performed among the subset of 44 patients who had treatment-refractory leiomyosarcoma, liposarcoma, or undifferentiated pleomorphic sarcoma.
Posted In: BCAB
