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The growing body of information regarding Isoray, Inc.'s (NYSE:ISR) Cesium-131 in treating prostate cancer was highlighted in two presentations at the just concluded American Brachytherapy Society's annual conference in Denver, Colorado.
During the conference, the Prostate Snap Oral I scientific session included two abstracts that were presented by The Cesium Advisory Group. The group is comprised of five experienced physicians with extensive experience using Cesium-131 monotherapy for permanent prostate brachytherapy who came together to form the advisory group.
Commenting on the presentations, Isoray CEO Lori Woods said, "Long-term outcomes have demonstrated the significance of Cesium-131 brachytherapy for prostate cancer treatment. These abstracts present valuable information for clinicians on achieving the best possible implant based on the recommendations of experienced Cesium-131 users. They leverage a substantial experience base built over some 15 years for the benefit of current and future prostate brachytherapists. As innovators in brachytherapy, we continue to be proud of our leading brachytherapy treatment that is at the forefront in bringing important benefits to cancer patients and the medical professionals who care for them."
One of the presentations was entitled, Permanent LDR brachytherapy using Cesium-131 Monotherapy: Updated Recommendations from the Cesium Advisory Group, by authors Brian J. Moran, MD, Bradley Prestidge, MD, MS, Steven Kurtzman, MD, David T. Marshall, MD, MS, Bernard W. Taylor Jr., MD, and Roksana Tech, MD.
The authors noted that Cesium-131 has a higher photon energy as well as a shorter half-life in comparison to its counterparts, Iodine-125 and Palladium-103. They stated that the optimal Cesium-131 implant will deliver a safe and effective dose with the minimum possible toxicity. A review of implant techniques examining variability and/or similarity of different sized prostates for each brachytherapist was undertaken. The data acquired was compared to the past Cesium Advisory Group's 2008 recommendations.
The advisory group recommended "homogenous" implants capable of delivering a cancer-killing dose to the prostate gland with as few hot and cold spots as possible. Hot spots deliver more radiation than is necessary, while cold spots may undertreat cancer in the gland. Very homogenous implants are possible with Cesium-131 due to the greater energy of Cesium-131 as compared to some other isotopes. By delivering a dose with Cesium-131 that lacks hot and cold spots and that spares the bladder and rectum, an effective radiation dose may possibly be administered with minimal side effects experienced by the patient. Compared to the 2008 recommendations, they found that the amount of the urethra that receives 30% of the prescription dose (uD30) continues to be less than 140% and the amount of the entire prostate receiving 150% of the prescription dose (pV150) has decreased from <45% to ~20-40%.
The Cesium Advisory Group's second presentation was entitled, Technique and Preferences for Permanent LDR Prostate Brachytherapy Using Cesium-131. The purpose of their study was to identify individual technique preferences for Cesium-131 prostate implantation and determine if there is a uniform method among the brachytherapists.
While Cesium-131 implants vary on several specifics with regards to technique, the brachytherapists on the panel are uniform in their practice to implant the majority of the Cesium-131 isotope in the periphery. This so-called "peripheral loading" takes dose away from the urethra where it might cause unwanted urinary symptoms. No matter how the Cesium-131 implant is planned and administered, homogeneity and sparing of the nearby sensitive anatomy is recommended and achievable.
The members of the Cesium Advisory Group (CAG) who compiled these reports have performed over 6,000 implants as a group over the years since the introduction of Cesium-131 as a treatment for prostate cancer.
Isoray is a medical technology company and innovator in seed brachytherapy. The Company is the world's only producer of Cesium-131 brachytherapy, commercially known as Cesium Blu, which is powering expanding internal radiation treatment options throughout the body for prostate cancer as well as difficult to treat lung, brain, gynecological, head and neck, pelvic, and colorectal cancers .
Posted In: ISR
