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PHILADELPHIA and VANCOUVER, British Columbia, Dec. 06, 2023 (GLOBE NEWSWIRE) -- BriaCell Therapeutics Corp. (NASDAQ:BCTX, BCTXW))))) (TSX:BCT) ("BriaCell" or the "Company"), a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care, is presenting 3 posters including two today at the 2023 San Antonio Breast Cancer Symposium® at Henry B. Gonzalez Convention Center, San Antonio, TX.
Today's posters highlight the activation of cancer fighting immune cells by the Bria-IMT™ combination regimen that was identified using leading-edge technologies. These tools may be used to evaluate immune system responses to immunotherapy treatments, and perhaps to predict survival and clinical benefit in cancer patients treated with the Bria-IMT™ regimen.
"I am very excited with our findings using advanced CD8 ImmunoPET imaging that may be able to transform the way we treat cancer patients," stated Russ Kuker, M.D., Associate Professor of Clinical Radiology at the University of Miami Miller School of Medicine and the first author of the PO1-20-12 poster. "We were able to see that the Bria-IMT™ combination regimen treatment can activate cancer-fighting T cells to infiltrate some breast cancer tumors. This represents evidence of the effectiveness of the Bria-IMT™ combination regimen and demonstrates the potential of this approach."
"I am thrilled with the successful transformation of a cold immune suppressed tumor to a hot immune responsive one as well as the antibody responses seen with our immunotherapy," stated Dr. William V. Williams, BriaCell's President and CEO. "We strongly believe in the potential of our novel immunotherapy in cancer patients and will be working determinedly with experts to bring these safe and effective treatment options to cancer patients who have failed other therapies."
Poster #1 Abstract Title: CD8+ Tumor Infiltrating Lymphocytes Turn a Cold Tumor Hot in Metastatic Breast Cancer
Submission ID: 1577766
Presentation ID: PO1-20-12
Spotlight Session: Poster Session 1
Session Date and Time: Wednesday December 6, 2023 12:00 PM - 2:00 PM CT
Bria-IMT™ combination regimen with immune checkpoint inhibitors activated cancer-fighting CD8+ T cells turning "Cold" tumors "Hot" on ImmunoPET imaging
In summary, the use of leading technologies such as CD8 ImmunoPET imaging, peripheral blood tumor markers, and circulating cancer-associated cells demonstrate the therapeutic potential of the Bria-IMT™ combination therapy regimen. These findings support the use of this combination regimen in our pivotal Phase 3 study.
Poster #2 Abstract Title: Analysis of Antibody Response to SV-BR-1-GM Therapeutic Vaccine in Breast Cancer Patients Using Human Protein Microarrays: Potential Correlations with Therapy Response
Submission ID: 1578637
Presentation ID: PO2-13-06
Spotlight Session: Poster Session 2
Session Date and Time: Wednesday December 6, 2023 5:00 PM - 7:00 PM CT
Overall, BriaCell's data shows significant anti-tumor activity of its lead candidate, Bria-IMT™ (alone or in combination with immune check point inhibitors) in advanced metastatic breast cancer. Using innovative technologies, we believe that we have identified potential predictors of patients' survival following treatment with the Bria-IMT™ combination therapy regimen. We plan to further investigate these findings in our ongoing Phase 3 study in advanced metastatic breast cancer.
BriaCell's third poster of this meeting titled "Randomized Phase 2 of Bria-IMT™, an allogenic human cell line with antigen presenting activity, in heavily pretreated metastatic breast cancer; will present updated overall survival clinical data tomorrow 12:00 pm – 2:00 PM CT; Presentation ID: PO3-05-12".
Copies of the posters will be posted at the following: https://briacell.com/scientific-publications/.