NeuroBo To Present Latest Pre-Clinical Data On Cardiometabolic Assets, DA-1241 And DA-1726, Targeting MASH And Obesity, At Scientific Conferences In June

Author: Benzinga Newsdesk | April 30, 2024 08:28am

NeuroBo Pharmaceuticals, Inc. (NASDAQ:NRBO), a clinical-stage biotechnology company focused on the transformation of cardiometabolic diseases, today announced the acceptance of poster presentations for its promising cardiometabolic assets, DA-1241 and DA-1726, at the EASL Congress 2024 and the American Diabetes Association (ADA) 84th Scientific Sessions in June.

"Having multiple posters selected for presentation at two of the most esteemed scientific forums emphasizes the scientific community's recognition of the compelling pre-clinical data that we have generated for DA-1241 and DA-1726," stated Hyung Heon Kim, President and Chief Executive Officer of NeuroBo. "We have completed enrollment for Part 1 of our Phase 2a clinical trial of DA-1241, a novel G-Protein-Coupled Receptor 119 (GPR119) agonist for the treatment of metabolic dysfunction-associated steatohepatitis (MASH). Additionally, we have recently dosed the first patient in the single ascending dose (SAD) Part 1 of our Phase 1 trial of DA-1726, a novel, dual oxyntomodulin (OXM) analog agonist that functions as a glucagon-like peptide-1 receptor (GLP1R) and glucagon receptor (GCGR) for the treatment of obesity. DA-1726 has consistently shown, in our preclinical data, to sustain weight loss in diet-induced obese models by decreasing food consumption and boosting energy expenditure. Both programs are progressing well, and we have been able to significantly accelerate the clinical timelines for DA-1726. We currently expect to both dose the first patient in the multiple ascending dose (MAD) Part 2 and read-out top-line data from the SAD Part 1 in the third quarter of 2024, with top-line data from the MAD Part 2 expected in the first quarter of 2025."

• June 5-8: EASL Congress 2024. Members of the Dong-A ST Research Center and DA-1241 Phase 2 trial Contract Research Organization (CRO), Gubra, will present pre-clinical data on DA-1241, in two poster presentations at this congress in Milan, Italy.
  
   
  • Abstract Title: DA-1241, a GPR119 Agonist, Combined with Semaglutide Synergistically Improved Liver Fibrosis in Mice with CCl4-Induced Liver Fibrosis
  • Authors: Il Hoon Jung, Tae Hyoung Kim, Sujin Lee, Yuna Chae, Hyung Heon Kim, Mi-Kyung Kim
  • Presenter Name: II Hoon Jung, Dong-A ST Research Center
  • Abstract Number: 117
  • Session: Poster - Fibrosis / Stellate cell biology
  • Session Date: Thursday, June 6, 2024
  • Session Time: 8:30 am – 6:00 pm CET
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  • Abstract Title: Additive Hepatoprotective Effects of DA-1241, a Novel GPR119 Agonist, in Combination with Semaglutide in the GAN Diet-Induced Obese and Biopsy-Confirmed Mouse Model of MASH
  • Authors: Monika Lewinska, Malte H. Nielsen, Susanne Pors, Henrik B. Hansen, Il Hoon Jung, Hyung Heon Kim, Michael Feigh, Mi-Kyung Kim
  • Presenter Name: Dr. Michael Feigh, Vice President Scientific Research, Gubra
  • Abstract Number: 1950
  • Session: Poster - MASLD: Experimental and pathophysiology
  • Session Date: Thursday, June 6, 2024
  • Session Time: 8:30 am – 6:00 pm CET
• June 21-24: American Diabetes Association (ADA) 84th Scientific Sessions. A member of the Dong-A ST Research Center will present pre-clinical data on DA-1726 in a poster presentation at this scientific session in Orlando, FL.
  
  
  
  
  • Abstract Title: DA-1726, a GLP1R/GCGR Dual Agonist, A Promising Approach in Obesity Treatment and Lipid Management
  • Presenter Name: Yuna Chae, DA-1726 Project Manager, Dong-A ST Research Center
  • Authors: Il-Hun Jung, Tae-Hyoung Kim, Su Jin Lee, Hyung Heon Kim, Mi-Kyung Kim, Yuna Chae
  • Abstract Number: 2024-LB-5728
  • Poster Presentation Number: 2058-LB
  • Session: 23-A Obesity-Animal
  • Session Date: Saturday, June 22, 2024
  • Session Time: 12:30 pm – 1:30 pm ET

After the presentations, the posters will be accessible within the "Presentations" section of NeuroBo's website at: https://www.neurobopharma.com/events-presentations/presentations.

Posted In: NRBO