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Entero Therapeutics, Inc., (NASDAQ:ENTO), ("Entero Therapeutics" or the "Company"), a clinical-stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for gastrointestinal (GI) diseases, today announced the publication of "A Composite Morphometric Duodenal Biopsy Mucosal Scale for Celiac Disease Encompassing Both Morphology and Inflammation" in Clinical Gastroenterology and Hepatology, a pre-eminent journal of the American Gastroenterological Association (AGA) that publishes innovative diagnostic and therapeutic advances in clinical gastroenterology.
As the number of promising therapies for celiac disease (CeD) grows, so does the need to improve the measurement of clinically relevant histological endpoints. The new approach presented in a peer-reviewed publication, led by Jack Syage, Ph.D., President and Chief Scientific Officer of Entero Therapeutics, recognized the need to advance beyond qualitative measures of histologic small intestinal health and to develop a more accurate and sensitive scale based on the independent quantitative measures of architectural changes (villus height to crypt depth ratio, Vh:Cd) and inflammation (intraepithelial lymphocyte count, IEL) already in use. The team created a composite score (VCIEL) for these two measures that helps overcome the individual variances to improve the overall accuracy of histological evaluation. The publication demonstrated the significant benefits of the VCIEL scale based on the results of four previous clinical trials. The significance of this achievement was highlighted in a special editorial feature by the journal, demonstrating the importance of this novel metric to CeD researchers.
Posted In: ENTO
