Legend Biotech Reports Overall Survival Results Of Landmark Phase 3 CARTITUDE-4 Trial In Multiple Myeloma

Author: Benzinga Newsdesk | July 02, 2024 08:09am

Legend Biotech Corporation (NASDAQ:LEGN) (Legend Biotech), a global leader in cell therapy, announced today positive overall survival results from CARTITUDE-4, an ongoing, global randomized, open-label Phase 3 study evaluating the efficacy and safety of CARVYKTI® (ciltacabtagene autoleucel; cilta-cel) versus pomalidomide, bortezomib and dexamethasone (PVd) or daratumumab, pomalidomide, and dexamethasone (DPd) in adult patients with relapsed and lenalidomide-refractory multiple myeloma who received one to three prior lines of therapy, including a proteasome inhibitor (PI) and an immunomodulatory agent (IMiD). In the pre-specified second interim analysis of the trial, CARVYKTI® demonstrated statistically significant and clinically meaningful improvement in overall survival (OS).1 Safety results were consistent with the established safety profile of CARVYKTI®, and no new safety signals were identified.

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