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CERo Therapeutics To Present CER-1236 Data Supporting Use In AML At Global Cell & Gene Therapy Summit 2024; Anticipates Initial Human Trials To Focus On AML Upon IND Clearance

Author: Benzinga Newsdesk | July 08, 2024 08:13am

Company anticipates initial human trials to focus on AML upon IND clearance

SOUTH SAN FRANCISCO, Calif., July 08, 2024 (GLOBE NEWSWIRE) --  CERo Therapeutics Holdings, Inc. (NASDAQ:CERO) ("CERo"), an innovative immunotherapy company seeking to advance the next generation of engineered T cell therapeutics that employ phagocytic mechanisms, announces presentation of a poster on its lead compound CER-1236 at the Global Cell & Gene Therapy Summit 2024.  The conference is being held July 8-10 in Boston.    

The poster, titled, "Aberrant Expression of TIM-4-L is a Common Feature of AML and Potential Target for Engineered T Cell Therapy" presents data showing that TIM-4-L is prevalent on multiple acute myeloid leukemia (AML) subsets, but not present in healthy tissue.  The study continues that CER-1236, CERo's lead compound, showed potent in vitro and in vivo cytotoxicity against TP53 mutant AML.  Further, a full-scale toxicity study revealed that CER-1236 T cells engraft in lymphoid tissues, but do not cause any in-life observations, clinical pathology, or histopathological evaluations.  This indicates that CER-1236 is not associated with any adverse toxicities against healthy tissue, even at high doses.  The poster, which is being presented on July 8, 2024, can be accessed here.

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