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HC Wainwright initiated coverage on Enliven Therapeutics, Inc. (NASDAQ:ELVN) and noted the company as an emerging biotech company developing next-gen precision-oriented small molecules for solid and liquid tumor indications.
Enliven’s pipeline includes:
The analyst initiates with a Buy rating and a price target of $37.
CML is a chronic disease requiring multiple years of continuous treatment. Patients frequently switch therapies due to liabilities of the existing approved drugs, including poor tolerability due to off-target effects and inability to dose to maximal efficacy.
Six approved drugs—Novartis AG’s (NYSE:NVS) Gleevec (imatinib), Scemblix (asciminib), and Tasigna (nilotinib), Bristol-Myers Squibb & Co’s (NYSE:BMY) Sprycel (dasatinib), Pfizer Inc (NYSE:PFE) Bosulif (bosutinib), and Takeda Pharmaceutical Co Ltd (NYSE:TAK) Iclusig (ponatinib)—generate over $6 billion in annual sales, with each drug bringing in around $500 million. Some even achieve peak annual sales of up to $2 billion despite competition from generic versions.
HC Wainwright analyst projects that positioning ELVN-001 as a third-line treatment could surpass $500 million in peak annual sales.
ELVN-002 has the potential to address unmet needs in HER2-mutant NSCLC, CRC, and mBC, where current treatments have limitations. It could challenge competitors like Pfizer’s Tukysa and tap into the growing post-AstraZeneca Plc (NASDAQ:AZN) Enhertu market, with sales possibly reaching hundreds of millions.
While Enliven focuses on precision oncology, its target market is broader than that of past agents like Bristol-Myers’ Augtyro (repotrectinib) and Roche Holdings AG’s (OTC:RHHBY) Rozlytrek (entrectinib).
Price Action: ELVN stock is up 7.32% at $23.01 at the last check on Monday.
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