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– Data demonstrates Kronos Bio's approach to targeting oncogenic transcription factors and the strong relationship between IRF4 and p300 in Multiple Myeloma –
– Poster presentation to take place on Monday, December 9, 2024 –
SAN MATEO, Calif. and CAMBRIDGE, Mass., Nov. 05, 2024 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (NASDAQ:KRON), a company dedicated to developing small molecule therapeutics that address cancers and autoimmune diseases driven by deregulated transcription, today announced that it will present preclinical data from its p300 KAT inhibitor program for multiple myeloma at the American Society of Hematology (ASH) Annual Meeting taking place in San Diego, California from December 7 to 10, 2024.
Kronos Bio is exploring the utility of its p300 KAT inhibitor, KB-9558, for multiple myeloma as well as HPV-driven tumors. In the presentation of preclinical data from the multiple myeloma program, the authors show that a context-specific and strong relationship exists between transcription factor interferon regulatory factor 4 (IRF4) and p300, a protein that impacts genes that are linked to cancer cell proliferation and survival. Furthermore, IRF4 and p300 display a preferential protein-protein interaction via a statistically similar network of interactors which was not evident with other transcription factors tested.
Posted In: KRON
