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Actinium Highlights Mutation Agnostic Antileukemic Activity Of Actimab-A Against FLT3, NPM1, KMT2A And TP53 Mutations in AML Models Demonstrating Backbone Potential For Acute Myeloid Leukemia Treatment

Author: Benzinga Newsdesk | April 28, 2025 08:12am

Actimab-A significantly potentiated and prolonged efficacy in combination with standard of care targeted therapies including hypomethylating agent azacitidine, FLT3 and menin inhibitors in in-vivo AML models
Actimab-A is the only CD33 targeted radiotherapy with Actinium-225 isotope payload in development for AML and other myeloid malignancies
- Actimab-A is currently being advanced in several combination studies including a Phase 2/3 trial in combination with CLAG-M in relapsed/refractory AML and in combination with Venetoclax and ASTX-727, an oral hypomethylating agent from Taiho Oncology in frontline AML under a CRADA with the NCI

Posted In: ATNM