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N-trans-caffeoyltyramine (NCT) is a natural bioactive compound attracting considerable interest from researchers for its potential role in healthy liver fat metabolism, gut barrier function, and mitochondrial activity.
Using eXoZymes' AI-driven platform, a new and proprietary approach to biomanufacturing of NCT - with all the scale-up advantages of an exozyme biosolution - has been developed: Progressing from concept to lab scale validation with gram-scale production in only 5 months and at a fraction of normal SynBio R&D cost.
NCTx was created as a spin-out company to commercialize the NCT technology and is now able to provide early access partners, under material transfer agreement with product samples. NCTx and eXoZymes are actively looking to increase the number of partners.
LOS ANGELES, CALIFORNIA / ACCESS Newswire / July 22, 2025 / Today, eXoZymes Inc. (NASDAQ:EXOZ) ("eXoZymes") - a pioneer of AI-engineered enzymes that can transform sustainable feedstock into nutraceuticals, medicines, and other essential chemicals - together with its spinout NCTx, announced a breakthrough in biomanufacturing using their cell-free exozyme platform: From proof-of-concept to lab scale validation with gram-scale production in only 5 months.
This critical technical milestone validates the exozyme biosolution process design for NCT, enabling it to overcome a longstanding bottleneck in sourcing the NCT compound from nature, where it occurs only in trace amounts. Naturally found in quantities less than 0.014% per hemp seed, NCT has not been available at commercially viable qualities and quantities, severely limiting its otherwise immense market potential.
Successful completion of this milestone enables eXoZymes' team to initiate a comprehensive assessment of the purity profile. Separately, data collected on process-related parameters provides foundational de-risking information for the biomanufacturing economic assumptions and allows eXoZymes to expand the number of early access partners.
Posted In: EXOZ
