Synopsys, Chewy, And The Trade Desk Are Among Top 10 Large Cap Losers Last Week (Sep. 8- Sep. 12): Are The Others In Your Portfolio?

Author: Nabaparna Bhattacharya | September 14, 2025 11:01am

These ten large-cap stocks were the worst performers last week. Are they a part of your portfolio?

1. Synopsys, Inc. (NASDAQ:SNPS) lost 29.20% this week after after the company reported worse-than-expected financial results and issued fourth quarter adjusted earnings per share guidance below estimates on Tuesday after the market closed. Also, the company cut its fiscal-year 2025 adjusted earnings per share guidance below estimates.
2. Summit Therapeutics Inc. (NASDAQ:SMMT) stock lost 11.8% this week after revealed the updated overall survival (OS) results from the global Phase 3 HARMONi trial of ivonescimab at the 2025 World Conference on Lung Cancer (WCLC).
3. Chewy, Inc. (NYSE:CHWY) stock lost 18.05% this week after the company reported second-quarter financial results. Also, multiple analysts lowered their price forecasts on the stock.
4. Rubrik, Inc. (NYSE:RBRK) stock decreased 20.74% this week after the company reported second-quarter results.
5. BioNTech SE (NASDAQ:BNTX) stock fell 11.84% this week. The company and Bristol Myers Squibb presented interim data from global randomized phase 2 trial evaluating Pumitamig an investigational bispecific antibody targeting PD-L1 X VEGF-A, plus chemotherapy in ES-SCLC patients.
6. The Trade Desk, Inc. (NASDAQ:TTD) stock decreased 13.75% this week after Morgan Stanley downgraded the stock from Overweight to Equal-Weight and cut its price forecast from $80 to $50.
7. Ferguson Enterprises Inc.  (NYSE:FERG) stock declined 11.18% this week. Barclays maintained their Buy rating on the stock.
8. Humana Inc. (NYSE:HUM) stock decreased 10.32% this week.
9. Samsara Inc. (NYSE:IOT) stock fell 9.38% this week. Morgan Stanley analyst Keith Weiss maintains a Equal-Weight, raising the price forecast from $50 to $53.
10. Burlington Stores, Inc. (NYSE:BURL) stock fell 8.43% this week.
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Posted In: BNTX BURL CHWY FERG HUM IOT RBRK SMMT SNPS TTD