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Reported Sunday, Regeneron's DB-OTO Gene Therapy Yields Sustained Hearing Restoration And Speech Perception Gains In OTOF-Related Hearing Loss

Author: Benzinga Newsdesk | October 13, 2025 02:39am

Nearly all participants (11 of 12) experienced clinically meaningful hearing improvements, including three who achieved normal hearing; eight with longer follow-up showed stability or continued improvement in their hearing

Among three who completed speech assessments, all showed significant improvement with one able to identify one- and two-syllable words with no visual cues and respond to distant sounds and speech in noisy environments

Latest DB-OTO data presented at AAO-HNSF; U.S. regulatory submission planned later this year, pending discussions with the FDA

Posted In: REGN

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